Interactions of Endoxifen and other major metabolites of Tamoxifen with human sulfotransferases SULT2A1, SULT1E1, and SULT1A1*1 : implications for the therapeutic action and toxicity of Tamoxifen

Recommended Citation Squirewell, Edwin Jermaine. "Interactions of Endoxifen and other major metabolites of Tamoxifen with human sulfotransferases SULT2A1, SULT1E1, and SULT1A1*1 : implications for the therapeutic action and toxicity of Tamoxifen." PhD (Doctor of Philosophy) thesis, ii To Him who is able to do immeasurably more than all we ask or imagine, according to His power that is at work within us, to Him be glory in the Church and in Christ Jesus throughout all generations, forever and ever! Amen. iii ACKNOWLEDGMENTS There are not enough words to fully express my gratitude and thanks to those who have contributed to my personal development as a scientist and as well as my personal life outside of research. To my mentor, Professor Michael Duffel, thank you so much for your unconditional help, guidance, and support throughout my graduate career. You are a teacher and friend. We rejoiced together with each new discovery in my research, and you helped me through each hurdle in graduate school with a positive attitude. Thank you for understanding my medical needs and health concerns. You are approachable, and you counseled me through numerous times of frustration and anger. You made me feel appreciated and gave me confidence in times where I questioned my own abilities. I'm proud to be a product of your laboratory and a carrier of your name throughout the remainder of my career. To my doctoral committee members (Drs. I want to show my great appreciation for your efforts in helping me to obtain this PhD degree. Whether in the classroom or in the hallways, you each greeted me with a warm, friendly welcome and enhanced my understanding of medicinal chemistry through coursework and discussion. Thank you for the letters of recommendation and the cooking tips (i.e. Dr. Quinn). Thank you, Drs. Roman and Kerns, for allowing me to use your lab-space at times during my thesis research. Also, thank you, Dr. Doorn, for granting me access to your " diabetes in a drawer " and informing me that the lab decorations were paper snakes, not giant colons. In addition, thank your for providing a quiet desk for concentration while in the midst of writing my dissertation. providing the assistance and training for my analytical work in the high resolution mass spectrometry and NMR facilities. You were each gracious in allowing me the use of your iv personal time in order to interpret and …